Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2051711..2052240 Replicon chromosome
Accession NZ_CP102971
Organism Staphylococcus aureus strain 08-G-E

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW975_RS10025 Protein ID WP_000621175.1
Coordinates 2051711..2052073 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW975_RS10030 Protein ID WP_000948331.1
Coordinates 2052070..2052240 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW975_RS10005 (NW975_10005) 2048689..2049459 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW975_RS10010 (NW975_10010) 2049434..2049913 - 480 WP_258413936.1 anti-sigma B factor RsbW -
NW975_RS10015 (NW975_10015) 2049915..2050241 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW975_RS10020 (NW975_10020) 2050360..2051361 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW975_RS10025 (NW975_10025) 2051711..2052073 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW975_RS10030 (NW975_10030) 2052070..2052240 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW975_RS10035 (NW975_10035) 2052325..2053473 - 1149 WP_001281154.1 alanine racemase -
NW975_RS10040 (NW975_10040) 2053539..2053898 - 360 WP_000581197.1 holo-ACP synthase -
NW975_RS10045 (NW975_10045) 2053902..2054393 - 492 WP_001205912.1 PH domain-containing protein -
NW975_RS10050 (NW975_10050) 2054380..2055963 - 1584 WP_258413937.1 PH domain-containing protein -
NW975_RS10055 (NW975_10055) 2055956..2056435 - 480 WP_001287078.1 hypothetical protein -
NW975_RS10060 (NW975_10060) 2056644..2057204 - 561 WP_061838823.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254741 WP_000621175.1 NZ_CP102971:c2052073-2051711 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254741 WP_000948331.1 NZ_CP102971:c2052240-2052070 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References