Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1893369..1894145 Replicon chromosome
Accession NZ_CP102971
Organism Staphylococcus aureus strain 08-G-E

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW975_RS09100 Protein ID WP_000031108.1
Coordinates 1893369..1893521 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW975_RS09105 Protein ID WP_001251224.1
Coordinates 1893546..1894145 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW975_RS09085 (NW975_09085) 1889398..1890219 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW975_RS09090 (NW975_09090) 1890682..1892067 - 1386 WP_258413920.1 class II fumarate hydratase -
NW975_RS09095 (NW975_09095) 1892263..1892658 - 396 WP_000901023.1 hypothetical protein -
NW975_RS09100 (NW975_09100) 1893369..1893521 - 153 WP_000031108.1 SAS053 family protein Toxin
NW975_RS09105 (NW975_09105) 1893546..1894145 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW975_RS09110 (NW975_09110) 1894304..1894774 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW975_RS09115 (NW975_09115) 1894779..1895906 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
NW975_RS09120 (NW975_09120) 1896057..1896779 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW975_RS09125 (NW975_09125) 1896772..1898229 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 1832645..1903326 70681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254740 WP_000031108.1 NZ_CP102971:c1893521-1893369 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254740 WP_001251224.1 NZ_CP102971:c1894145-1893546 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References