Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2514235..2514758 Replicon chromosome
Accession NZ_CP102970
Organism Staphylococcus aureus strain 09-G-F

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NW983_RS12480 Protein ID WP_258411852.1
Coordinates 2514235..2514501 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag NW983_RS12485 Protein ID WP_000587617.1
Coordinates 2514501..2514758 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW983_RS12460 (NW983_12460) 2509541..2510728 - 1188 WP_258411850.1 MFS transporter -
NW983_RS12465 (NW983_12465) 2511124..2511900 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
NW983_RS12470 (NW983_12470) 2511893..2512555 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
NW983_RS12475 (NW983_12475) 2512803..2513879 - 1077 WP_258411851.1 M42 family metallopeptidase -
NW983_RS12480 (NW983_12480) 2514235..2514501 - 267 WP_258411852.1 Txe/YoeB family addiction module toxin Toxin
NW983_RS12485 (NW983_12485) 2514501..2514758 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW983_RS12490 (NW983_12490) 2515117..2515572 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NW983_RS12495 (NW983_12495) 2515740..2517317 - 1578 WP_258411853.1 FMN-binding glutamate synthase family protein -
NW983_RS12500 (NW983_12500) 2517513..2518262 + 750 WP_006191031.1 CPBP family lipoprotein N-acylation protein LnsB -
NW983_RS12505 (NW983_12505) 2518486..2519679 - 1194 WP_258411854.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(28-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.37 Da        Isoelectric Point: 10.2763

>T254737 WP_258411852.1 NZ_CP102970:c2514501-2514235 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT254737 WP_000587617.1 NZ_CP102970:c2514758-2514501 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References