254731

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2074273..2074787 Replicon chromosome
Accession NZ_CP102970
Organism Staphylococcus aureus strain 09-G-F

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW983_RS10140 Protein ID WP_000581792.1
Coordinates 2074273..2074482 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW983_RS10145 Protein ID WP_000138932.1
Coordinates 2074494..2074787 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW983_RS10120 (NW983_10120) 2069781..2071139 - 1359 WP_258411762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW983_RS10125 (NW983_10125) 2071154..2072224 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW983_RS10130 (NW983_10130) 2072542..2073744 + 1203 WP_054190441.1 FtsW/RodA/SpoVE family cell cycle protein -
NW983_RS10135 (NW983_10135) 2074008..2074145 - 138 WP_000828354.1 Lmo0850 family protein -
NW983_RS10140 (NW983_10140) 2074273..2074482 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW983_RS10145 (NW983_10145) 2074494..2074787 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW983_RS10150 (NW983_10150) 2074953..2076437 + 1485 WP_000571549.1 cardiolipin synthase -
NW983_RS10155 (NW983_10155) 2076465..2077112 + 648 WP_258411763.1 HD domain-containing protein -
NW983_RS10160 (NW983_10160) 2077926..2078798 - 873 WP_258411764.1 membrane protein insertase YidC -
NW983_RS10165 (NW983_10165) 2078884..2079525 - 642 WP_258411765.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254731 WP_000581792.1 NZ_CP102970:c2074482-2074273 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254731 WP_000138932.1 NZ_CP102970:c2074787-2074494 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References