Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2054532..2055061 Replicon chromosome
Accession NZ_CP102970
Organism Staphylococcus aureus strain 09-G-F

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW983_RS10050 Protein ID WP_000621175.1
Coordinates 2054532..2054894 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW983_RS10055 Protein ID WP_000948331.1
Coordinates 2054891..2055061 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW983_RS10030 (NW983_10030) 2051510..2052280 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW983_RS10035 (NW983_10035) 2052255..2052734 - 480 WP_001190825.1 anti-sigma B factor RsbW -
NW983_RS10040 (NW983_10040) 2052736..2053062 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW983_RS10045 (NW983_10045) 2053181..2054182 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW983_RS10050 (NW983_10050) 2054532..2054894 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW983_RS10055 (NW983_10055) 2054891..2055061 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW983_RS10060 (NW983_10060) 2055146..2056294 - 1149 WP_252570666.1 alanine racemase -
NW983_RS10065 (NW983_10065) 2056360..2056719 - 360 WP_000581197.1 holo-ACP synthase -
NW983_RS10070 (NW983_10070) 2056723..2057214 - 492 WP_072353916.1 PH domain-containing protein -
NW983_RS10075 (NW983_10075) 2057201..2058784 - 1584 WP_045173493.1 PH domain-containing protein -
NW983_RS10080 (NW983_10080) 2058777..2059256 - 480 WP_258411759.1 hypothetical protein -
NW983_RS10085 (NW983_10085) 2059465..2060025 - 561 WP_103148787.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254730 WP_000621175.1 NZ_CP102970:c2054894-2054532 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254730 WP_000948331.1 NZ_CP102970:c2055061-2054891 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References