Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1902315..1903091 Replicon chromosome
Accession NZ_CP102970
Organism Staphylococcus aureus strain 09-G-F

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW983_RS09160 Protein ID WP_000031108.1
Coordinates 1902315..1902467 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW983_RS09165 Protein ID WP_001251224.1
Coordinates 1902492..1903091 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW983_RS09145 (NW983_09145) 1898045..1898866 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW983_RS09150 (NW983_09150) 1899327..1900712 - 1386 WP_000116231.1 class II fumarate hydratase -
NW983_RS09155 (NW983_09155) 1900908..1901303 - 396 WP_000901023.1 hypothetical protein -
NW983_RS09160 (NW983_09160) 1902315..1902467 - 153 WP_000031108.1 SAS053 family protein Toxin
NW983_RS09165 (NW983_09165) 1902492..1903091 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW983_RS09170 (NW983_09170) 1903250..1903720 - 471 WP_258411734.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW983_RS09175 (NW983_09175) 1903725..1904852 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW983_RS09180 (NW983_09180) 1905003..1905725 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW983_RS09185 (NW983_09185) 1905718..1907175 - 1458 WP_258411735.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254729 WP_000031108.1 NZ_CP102970:c1902467-1902315 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254729 WP_001251224.1 NZ_CP102970:c1903091-1902492 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References