Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2432596..2433119 Replicon chromosome
Accession NZ_CP102968
Organism Staphylococcus aureus strain 13-G-52

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag NW965_RS11895 Protein ID WP_000074049.1
Coordinates 2432596..2432862 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NW965_RS11900 Protein ID WP_061385136.1
Coordinates 2432862..2433119 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW965_RS11875 (NW965_11870) 2427903..2429090 - 1188 WP_000026189.1 MFS transporter -
NW965_RS11880 (NW965_11875) 2429486..2430262 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
NW965_RS11885 (NW965_11880) 2430255..2430917 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW965_RS11890 (NW965_11885) 2431165..2432241 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW965_RS11895 (NW965_11890) 2432596..2432862 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
NW965_RS11900 (NW965_11895) 2432862..2433119 - 258 WP_061385136.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW965_RS11905 (NW965_11900) 2433478..2433933 + 456 WP_000732076.1 DUF1307 domain-containing protein -
NW965_RS11910 (NW965_11905) 2434101..2435678 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NW965_RS11915 (NW965_11910) 2435873..2436622 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T254726 WP_000074049.1 NZ_CP102968:c2432862-2432596 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9773.75 Da        Isoelectric Point: 4.2086

>AT254726 WP_061385136.1 NZ_CP102968:c2433119-2432862 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWNNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure

References