Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2045777..2046291 Replicon chromosome
Accession NZ_CP102968
Organism Staphylococcus aureus strain 13-G-52

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW965_RS09915 Protein ID WP_000581792.1
Coordinates 2045777..2045986 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW965_RS09920 Protein ID WP_000138932.1
Coordinates 2045998..2046291 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW965_RS09895 (NW965_09895) 2041285..2042643 - 1359 WP_258411762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW965_RS09900 (NW965_09900) 2042658..2043728 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW965_RS09905 (NW965_09905) 2044046..2045248 + 1203 WP_054190441.1 FtsW/RodA/SpoVE family cell cycle protein -
NW965_RS09910 (NW965_09910) 2045512..2045649 - 138 WP_000828354.1 Lmo0850 family protein -
NW965_RS09915 (NW965_09915) 2045777..2045986 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW965_RS09920 (NW965_09920) 2045998..2046291 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW965_RS09925 (NW965_09925) 2046457..2047941 + 1485 WP_000571549.1 cardiolipin synthase -
NW965_RS09930 (NW965_09930) 2047969..2048616 + 648 WP_258411763.1 HD domain-containing protein -
NW965_RS09935 (NW965_09935) 2049430..2050302 - 873 WP_000725802.1 membrane protein insertase YidC -
NW965_RS09940 (NW965_09940) 2050388..2051029 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254722 WP_000581792.1 NZ_CP102968:c2045986-2045777 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254722 WP_000138932.1 NZ_CP102968:c2046291-2045998 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References