Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2026036..2026565 Replicon chromosome
Accession NZ_CP102968
Organism Staphylococcus aureus strain 13-G-52

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW965_RS09825 Protein ID WP_000621175.1
Coordinates 2026036..2026398 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW965_RS09830 Protein ID WP_000948331.1
Coordinates 2026395..2026565 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW965_RS09805 (NW965_09805) 2023014..2023784 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW965_RS09810 (NW965_09810) 2023759..2024238 - 480 WP_258413936.1 anti-sigma B factor RsbW -
NW965_RS09815 (NW965_09815) 2024240..2024566 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW965_RS09820 (NW965_09820) 2024685..2025686 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW965_RS09825 (NW965_09825) 2026036..2026398 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW965_RS09830 (NW965_09830) 2026395..2026565 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW965_RS09835 (NW965_09835) 2026650..2027798 - 1149 WP_001281154.1 alanine racemase -
NW965_RS09840 (NW965_09840) 2027864..2028223 - 360 WP_000581197.1 holo-ACP synthase -
NW965_RS09845 (NW965_09845) 2028227..2028718 - 492 WP_001205912.1 PH domain-containing protein -
NW965_RS09850 (NW965_09850) 2028705..2030288 - 1584 WP_258413937.1 PH domain-containing protein -
NW965_RS09855 (NW965_09855) 2030281..2030760 - 480 WP_001287078.1 hypothetical protein -
NW965_RS09860 (NW965_09860) 2030969..2031529 - 561 WP_061838823.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254721 WP_000621175.1 NZ_CP102968:c2026398-2026036 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254721 WP_000948331.1 NZ_CP102968:c2026565-2026395 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References