Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1862319..1863095 Replicon chromosome
Accession NZ_CP102968
Organism Staphylococcus aureus strain 13-G-52

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW965_RS08875 Protein ID WP_000031108.1
Coordinates 1862319..1862471 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW965_RS08880 Protein ID WP_001251224.1
Coordinates 1862496..1863095 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW965_RS08860 (NW965_08860) 1858348..1859169 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW965_RS08865 (NW965_08865) 1859632..1861017 - 1386 WP_258413920.1 class II fumarate hydratase -
NW965_RS08870 (NW965_08870) 1861213..1861608 - 396 WP_000901023.1 hypothetical protein -
NW965_RS08875 (NW965_08875) 1862319..1862471 - 153 WP_000031108.1 SAS053 family protein Toxin
NW965_RS08880 (NW965_08880) 1862496..1863095 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW965_RS08885 (NW965_08885) 1863254..1863724 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW965_RS08890 (NW965_08890) 1863729..1864856 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
NW965_RS08895 (NW965_08895) 1865007..1865729 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW965_RS08900 (NW965_08900) 1865722..1867179 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254720 WP_000031108.1 NZ_CP102968:c1862471-1862319 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254720 WP_001251224.1 NZ_CP102968:c1863095-1862496 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References