Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsaAT/-
Location 817906..818383 Replicon chromosome
Accession NZ_CP102968
Organism Staphylococcus aureus strain 13-G-52

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag NW965_RS03830 Protein ID WP_000052076.1
Coordinates 817906..818094 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag NW965_RS03835 Protein ID WP_001059690.1
Coordinates 818123..818383 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW965_RS03800 (NW965_03795) 813947..814417 + 471 WP_000824472.1 hypothetical protein -
NW965_RS03805 (NW965_03800) 814758..815444 + 687 WP_001641381.1 thermonuclease family protein -
NW965_RS03810 (NW965_03805) 815801..816001 + 201 WP_001059082.1 cold-shock protein -
NW965_RS03815 (NW965_03810) 816497..816715 - 219 WP_000005886.1 hypothetical protein -
NW965_RS03820 (NW965_03815) 816777..817061 - 285 WP_001004401.1 hypothetical protein -
NW965_RS03825 (NW965_03820) 817149..817718 - 570 WP_072497911.1 lipoprotein N-acylation protein LnsA -
NW965_RS03830 (NW965_03825) 817906..818094 - 189 WP_000052076.1 hypothetical protein Toxin
NW965_RS03835 (NW965_03830) 818123..818383 - 261 WP_001059690.1 hypothetical protein Antitoxin
NW965_RS03840 (NW965_03835) 818724..818927 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
NW965_RS03845 (NW965_03840) 818924..819160 - 237 WP_000368687.1 hypothetical protein -
NW965_RS03850 (NW965_03845) 819384..819965 + 582 WP_001140693.1 histidine phosphatase family protein -
NW965_RS03855 (NW965_03850) 820038..820655 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
NW965_RS03860 (NW965_03855) 820810..821304 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
NW965_RS03865 (NW965_03860) 821703..822125 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
NW965_RS03870 (NW965_03865) 822273..822989 + 717 WP_258411042.1 type I 3-dehydroquinate dehydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T254718 WP_000052076.1 NZ_CP102968:c818094-817906 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp


Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT254718 WP_001059690.1 NZ_CP102968:c818383-818123 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References