Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2059923..2060452 Replicon chromosome
Accession NZ_CP102967
Organism Staphylococcus aureus strain 17-H-61

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW947_RS10115 Protein ID WP_000621175.1
Coordinates 2059923..2060285 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW947_RS10120 Protein ID WP_000948331.1
Coordinates 2060282..2060452 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW947_RS10095 (NW947_10095) 2056901..2057671 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
NW947_RS10100 (NW947_10100) 2057646..2058125 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW947_RS10105 (NW947_10105) 2058127..2058453 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW947_RS10110 (NW947_10110) 2058572..2059573 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW947_RS10115 (NW947_10115) 2059923..2060285 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW947_RS10120 (NW947_10120) 2060282..2060452 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW947_RS10125 (NW947_10125) 2060537..2061685 - 1149 WP_001281154.1 alanine racemase -
NW947_RS10130 (NW947_10130) 2061751..2062110 - 360 WP_000581197.1 holo-ACP synthase -
NW947_RS10135 (NW947_10135) 2062114..2062605 - 492 WP_001205912.1 PH domain-containing protein -
NW947_RS10140 (NW947_10140) 2062592..2064175 - 1584 WP_258416268.1 PH domain-containing protein -
NW947_RS10145 (NW947_10145) 2064168..2064647 - 480 WP_001287079.1 hypothetical protein -
NW947_RS10150 (NW947_10150) 2064856..2065416 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254713 WP_000621175.1 NZ_CP102967:c2060285-2059923 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254713 WP_000948331.1 NZ_CP102967:c2060452-2060282 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References