Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1906255..1907031 Replicon chromosome
Accession NZ_CP102967
Organism Staphylococcus aureus strain 17-H-61

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW947_RS09225 Protein ID WP_000031108.1
Coordinates 1906255..1906407 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW947_RS09230 Protein ID WP_001251224.1
Coordinates 1906432..1907031 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW947_RS09210 (NW947_09210) 1902276..1903097 + 822 WP_045174097.1 RluA family pseudouridine synthase -
NW947_RS09215 (NW947_09215) 1903560..1904945 - 1386 WP_045174099.1 class II fumarate hydratase -
NW947_RS09220 (NW947_09220) 1905141..1905536 - 396 WP_000901023.1 hypothetical protein -
NW947_RS09225 (NW947_09225) 1906255..1906407 - 153 WP_000031108.1 SAS053 family protein Toxin
NW947_RS09230 (NW947_09230) 1906432..1907031 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW947_RS09235 (NW947_09235) 1907189..1907659 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW947_RS09240 (NW947_09240) 1907664..1908791 - 1128 WP_000379985.1 tRNA epoxyqueuosine(34) reductase QueG -
NW947_RS09245 (NW947_09245) 1908942..1909664 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW947_RS09250 (NW947_09250) 1909657..1911114 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254712 WP_000031108.1 NZ_CP102967:c1906407-1906255 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254712 WP_001251224.1 NZ_CP102967:c1907031-1906432 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References