Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2475867..2476390 Replicon chromosome
Accession NZ_CP102966
Organism Staphylococcus aureus strain 29-P-01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NW955_RS12245 Protein ID WP_258412665.1
Coordinates 2475867..2476133 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag NW955_RS12250 Protein ID WP_000587617.1
Coordinates 2476133..2476390 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW955_RS12225 (NW955_12225) 2471172..2472359 - 1188 WP_000026189.1 MFS transporter -
NW955_RS12230 (NW955_12230) 2472755..2473531 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW955_RS12235 (NW955_12235) 2473524..2474186 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW955_RS12240 (NW955_12240) 2474434..2475510 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW955_RS12245 (NW955_12245) 2475867..2476133 - 267 WP_258412665.1 Txe/YoeB family addiction module toxin Toxin
NW955_RS12250 (NW955_12250) 2476133..2476390 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW955_RS12255 (NW955_12255) 2476750..2477205 + 456 WP_000732076.1 DUF1307 domain-containing protein -
NW955_RS12260 (NW955_12260) 2477373..2478950 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NW955_RS12265 (NW955_12265) 2479145..2479894 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10704.30 Da        Isoelectric Point: 10.1597

>T254710 WP_258412665.1 NZ_CP102966:c2476133-2475867 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHTYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT254710 WP_000587617.1 NZ_CP102966:c2476390-2476133 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References