254706

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2084435..2084949 Replicon chromosome
Accession NZ_CP102966
Organism Staphylococcus aureus strain 29-P-01

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW955_RS10235 Protein ID WP_000581792.1
Coordinates 2084435..2084644 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW955_RS10240 Protein ID WP_000138932.1
Coordinates 2084656..2084949 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW955_RS10215 (NW955_10215) 2079943..2081301 - 1359 WP_258411762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW955_RS10220 (NW955_10220) 2081316..2082386 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW955_RS10225 (NW955_10225) 2082704..2083906 + 1203 WP_054190441.1 FtsW/RodA/SpoVE family cell cycle protein -
NW955_RS10230 (NW955_10230) 2084170..2084307 - 138 WP_000828354.1 Lmo0850 family protein -
NW955_RS10235 (NW955_10235) 2084435..2084644 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW955_RS10240 (NW955_10240) 2084656..2084949 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW955_RS10245 (NW955_10245) 2085115..2086599 + 1485 WP_000571549.1 cardiolipin synthase -
NW955_RS10250 (NW955_10250) 2086627..2087274 + 648 WP_258411763.1 HD domain-containing protein -
NW955_RS10255 (NW955_10255) 2088088..2088960 - 873 WP_000725802.1 membrane protein insertase YidC -
NW955_RS10260 (NW955_10260) 2089046..2089687 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254706 WP_000581792.1 NZ_CP102966:c2084644-2084435 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254706 WP_000138932.1 NZ_CP102966:c2084949-2084656 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References