254705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2064694..2065223 Replicon chromosome
Accession NZ_CP102966
Organism Staphylococcus aureus strain 29-P-01

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW955_RS10145 Protein ID WP_000621175.1
Coordinates 2064694..2065056 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW955_RS10150 Protein ID WP_000948331.1
Coordinates 2065053..2065223 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW955_RS10125 (NW955_10125) 2061673..2062443 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW955_RS10130 (NW955_10130) 2062418..2062897 - 480 WP_001190825.1 anti-sigma B factor RsbW -
NW955_RS10135 (NW955_10135) 2062899..2063225 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW955_RS10140 (NW955_10140) 2063344..2064345 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW955_RS10145 (NW955_10145) 2064694..2065056 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW955_RS10150 (NW955_10150) 2065053..2065223 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW955_RS10155 (NW955_10155) 2065308..2066456 - 1149 WP_001281145.1 alanine racemase -
NW955_RS10160 (NW955_10160) 2066522..2066881 - 360 WP_000581197.1 holo-ACP synthase -
NW955_RS10165 (NW955_10165) 2066885..2067376 - 492 WP_072353916.1 PH domain-containing protein -
NW955_RS10170 (NW955_10170) 2067363..2068946 - 1584 WP_045173493.1 PH domain-containing protein -
NW955_RS10175 (NW955_10175) 2068939..2069418 - 480 WP_258411759.1 hypothetical protein -
NW955_RS10180 (NW955_10180) 2069627..2070187 - 561 WP_103148787.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254705 WP_000621175.1 NZ_CP102966:c2065056-2064694 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254705 WP_000948331.1 NZ_CP102966:c2065223-2065053 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References