Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2120640..2121154 Replicon chromosome
Accession NZ_CP102963
Organism Staphylococcus aureus strain 40-B-50

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW941_RS10460 Protein ID WP_000581792.1
Coordinates 2120640..2120849 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW941_RS10465 Protein ID WP_000138932.1
Coordinates 2120861..2121154 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW941_RS10440 (NW941_10475) 2116148..2117506 - 1359 WP_258415059.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW941_RS10445 (NW941_10480) 2117521..2118591 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW941_RS10450 (NW941_10485) 2118909..2120111 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW941_RS10455 (NW941_10490) 2120375..2120512 - 138 WP_000828354.1 Lmo0850 family protein -
NW941_RS10460 (NW941_10495) 2120640..2120849 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW941_RS10465 (NW941_10500) 2120861..2121154 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW941_RS10470 (NW941_10505) 2121320..2122804 + 1485 WP_000571549.1 cardiolipin synthase -
NW941_RS10475 (NW941_10510) 2122832..2123479 + 648 WP_001187630.1 HD domain-containing protein -
NW941_RS10480 (NW941_10515) 2124396..2125268 - 873 WP_000725802.1 membrane protein insertase YidC -
NW941_RS10485 (NW941_10520) 2125354..2125995 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254694 WP_000581792.1 NZ_CP102963:c2120849-2120640 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254694 WP_000138932.1 NZ_CP102963:c2121154-2120861 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References