254693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2100883..2101412 Replicon chromosome
Accession NZ_CP102963
Organism Staphylococcus aureus strain 40-B-50

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW941_RS10370 Protein ID WP_000621175.1
Coordinates 2100883..2101245 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW941_RS10375 Protein ID WP_000948331.1
Coordinates 2101242..2101412 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW941_RS10350 (NW941_10385) 2097861..2098631 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW941_RS10355 (NW941_10390) 2098606..2099085 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW941_RS10360 (NW941_10395) 2099087..2099413 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW941_RS10365 (NW941_10400) 2099532..2100533 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW941_RS10370 (NW941_10405) 2100883..2101245 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW941_RS10375 (NW941_10410) 2101242..2101412 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW941_RS10380 (NW941_10415) 2101497..2102645 - 1149 WP_001281151.1 alanine racemase -
NW941_RS10385 (NW941_10420) 2102711..2103070 - 360 WP_000581200.1 holo-ACP synthase -
NW941_RS10390 (NW941_10425) 2103074..2103565 - 492 WP_001205910.1 PH domain-containing protein -
NW941_RS10395 (NW941_10430) 2103552..2105135 - 1584 WP_001294620.1 PH domain-containing protein -
NW941_RS10400 (NW941_10435) 2105128..2105607 - 480 WP_001287079.1 hypothetical protein -
NW941_RS10405 (NW941_10440) 2105816..2106376 - 561 WP_258415057.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254693 WP_000621175.1 NZ_CP102963:c2101245-2100883 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254693 WP_000948331.1 NZ_CP102963:c2101412-2101242 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References