Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1939903..1940679 Replicon chromosome
Accession NZ_CP102963
Organism Staphylococcus aureus strain 40-B-50

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW941_RS09435 Protein ID WP_000031108.1
Coordinates 1939903..1940055 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW941_RS09440 Protein ID WP_001251224.1
Coordinates 1940080..1940679 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW941_RS09420 (NW941_09455) 1935932..1936753 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW941_RS09425 (NW941_09460) 1937216..1938601 - 1386 WP_000116229.1 class II fumarate hydratase -
NW941_RS09430 (NW941_09465) 1938797..1939192 - 396 WP_000901021.1 hypothetical protein -
NW941_RS09435 (NW941_09470) 1939903..1940055 - 153 WP_000031108.1 SAS053 family protein Toxin
NW941_RS09440 (NW941_09475) 1940080..1940679 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW941_RS09445 (NW941_09480) 1940839..1941309 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW941_RS09450 (NW941_09485) 1941314..1942441 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
NW941_RS09455 (NW941_09490) 1942592..1943314 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW941_RS09460 (NW941_09495) 1943307..1944764 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254692 WP_000031108.1 NZ_CP102963:c1940055-1939903 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254692 WP_001251224.1 NZ_CP102963:c1940679-1940080 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References