254683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2155971..2156485 Replicon chromosome
Accession NZ_CP102962
Organism Staphylococcus aureus strain 16CS0212

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag NW971_RS10735 Protein ID WP_117225677.1
Coordinates 2155971..2156180 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW971_RS10740 Protein ID WP_000138932.1
Coordinates 2156192..2156485 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW971_RS10715 (NW971_10715) 2151479..2152837 - 1359 WP_258464419.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW971_RS10720 (NW971_10720) 2152852..2153922 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW971_RS10725 (NW971_10725) 2154240..2155442 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW971_RS10730 (NW971_10730) 2155706..2155843 - 138 WP_000828354.1 Lmo0850 family protein -
NW971_RS10735 (NW971_10735) 2155971..2156180 - 210 WP_117225677.1 heavy metal-associated domain-containing protein Toxin
NW971_RS10740 (NW971_10740) 2156192..2156485 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW971_RS10745 (NW971_10745) 2156651..2158135 + 1485 WP_000571549.1 cardiolipin synthase -
NW971_RS10750 (NW971_10750) 2158163..2158810 + 648 WP_111762525.1 HD domain-containing protein -
NW971_RS10755 (NW971_10755) 2159576..2160448 - 873 WP_000725802.1 membrane protein insertase YidC -
NW971_RS10760 (NW971_10760) 2160534..2161175 - 642 WP_111762527.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254683 WP_117225677.1 NZ_CP102962:c2156180-2155971 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINLIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254683 WP_000138932.1 NZ_CP102962:c2156485-2156192 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References