Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2136231..2136760 Replicon chromosome
Accession NZ_CP102962
Organism Staphylococcus aureus strain 16CS0212

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW971_RS10645 Protein ID WP_000621175.1
Coordinates 2136231..2136593 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW971_RS10650 Protein ID WP_000948331.1
Coordinates 2136590..2136760 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW971_RS10625 (NW971_10625) 2133209..2133979 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW971_RS10630 (NW971_10630) 2133954..2134433 - 480 WP_001190825.1 anti-sigma B factor RsbW -
NW971_RS10635 (NW971_10635) 2134435..2134761 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW971_RS10640 (NW971_10640) 2134880..2135881 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW971_RS10645 (NW971_10645) 2136231..2136593 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW971_RS10650 (NW971_10650) 2136590..2136760 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW971_RS10655 (NW971_10655) 2136845..2137993 - 1149 WP_111762513.1 alanine racemase -
NW971_RS10660 (NW971_10660) 2138059..2138418 - 360 WP_000581197.1 holo-ACP synthase -
NW971_RS10665 (NW971_10665) 2138422..2138913 - 492 WP_001286981.1 PH domain-containing protein -
NW971_RS10670 (NW971_10670) 2138906..2140483 - 1578 WP_258464415.1 PH domain-containing protein -
NW971_RS10675 (NW971_10675) 2140476..2140955 - 480 WP_001287083.1 hypothetical protein -
NW971_RS10680 (NW971_10680) 2141164..2141724 - 561 WP_258464416.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254682 WP_000621175.1 NZ_CP102962:c2136593-2136231 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254682 WP_000948331.1 NZ_CP102962:c2136760-2136590 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References