Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1981470..1982246 Replicon chromosome
Accession NZ_CP102962
Organism Staphylococcus aureus strain 16CS0212

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW971_RS09755 Protein ID WP_000031108.1
Coordinates 1981470..1981622 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag NW971_RS09760 Protein ID WP_001251219.1
Coordinates 1981647..1982246 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW971_RS09740 (NW971_09740) 1977605..1978426 + 822 WP_258464373.1 RluA family pseudouridine synthase -
NW971_RS09745 (NW971_09745) 1978891..1980276 - 1386 WP_258464374.1 class II fumarate hydratase -
NW971_RS09750 (NW971_09750) 1980472..1980867 - 396 WP_000901023.1 hypothetical protein -
NW971_RS09755 (NW971_09755) 1981470..1981622 - 153 WP_000031108.1 SAS053 family protein Toxin
NW971_RS09760 (NW971_09760) 1981647..1982246 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
NW971_RS09765 (NW971_09765) 1982405..1982875 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW971_RS09770 (NW971_09770) 1982880..1984007 - 1128 WP_258464375.1 tRNA epoxyqueuosine(34) reductase QueG -
NW971_RS09775 (NW971_09775) 1984158..1984880 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW971_RS09780 (NW971_09780) 1984873..1986330 - 1458 WP_258464376.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254681 WP_000031108.1 NZ_CP102962:c1981622-1981470 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT254681 WP_001251219.1 NZ_CP102962:c1982246-1981647 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References