254670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2138657..2139171 Replicon chromosome
Accession NZ_CP102961
Organism Staphylococcus aureus strain 03-RR-88

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW973_RS10555 Protein ID WP_000581792.1
Coordinates 2138657..2138866 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW973_RS10560 Protein ID WP_000138932.1
Coordinates 2138878..2139171 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW973_RS10535 (NW973_10535) 2134165..2135523 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW973_RS10540 (NW973_10540) 2135538..2136608 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW973_RS10545 (NW973_10545) 2136926..2138128 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW973_RS10550 (NW973_10550) 2138392..2138529 - 138 WP_000828354.1 Lmo0850 family protein -
NW973_RS10555 (NW973_10555) 2138657..2138866 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW973_RS10560 (NW973_10560) 2138878..2139171 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW973_RS10565 (NW973_10565) 2139337..2140821 + 1485 WP_000571549.1 cardiolipin synthase -
NW973_RS10570 (NW973_10570) 2140849..2141496 + 648 WP_001187629.1 HD domain-containing protein -
NW973_RS10575 (NW973_10575) 2141962..2142834 - 873 WP_000725802.1 membrane protein insertase YidC -
NW973_RS10580 (NW973_10580) 2142920..2143561 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254670 WP_000581792.1 NZ_CP102961:c2138866-2138657 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254670 WP_000138932.1 NZ_CP102961:c2139171-2138878 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References