Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2118899..2119428 Replicon chromosome
Accession NZ_CP102961
Organism Staphylococcus aureus strain 03-RR-88

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW973_RS10465 Protein ID WP_000621175.1
Coordinates 2118899..2119261 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW973_RS10470 Protein ID WP_000948331.1
Coordinates 2119258..2119428 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW973_RS10445 (NW973_10445) 2115877..2116647 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW973_RS10450 (NW973_10450) 2116622..2117101 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW973_RS10455 (NW973_10455) 2117103..2117429 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW973_RS10460 (NW973_10460) 2117548..2118549 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW973_RS10465 (NW973_10465) 2118899..2119261 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW973_RS10470 (NW973_10470) 2119258..2119428 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW973_RS10475 (NW973_10475) 2119513..2120661 - 1149 WP_258410774.1 alanine racemase -
NW973_RS10480 (NW973_10480) 2120727..2121086 - 360 WP_061838820.1 holo-ACP synthase -
NW973_RS10485 (NW973_10485) 2121090..2121581 - 492 WP_258410775.1 PH domain-containing protein -
NW973_RS10490 (NW973_10490) 2121568..2123151 - 1584 WP_258410776.1 PH domain-containing protein -
NW973_RS10495 (NW973_10495) 2123144..2123623 - 480 WP_258410777.1 hypothetical protein -
NW973_RS10500 (NW973_10500) 2123832..2124392 - 561 WP_103148787.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254669 WP_000621175.1 NZ_CP102961:c2119261-2118899 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254669 WP_000948331.1 NZ_CP102961:c2119428-2119258 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References