Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1964705..1965481 Replicon chromosome
Accession NZ_CP102961
Organism Staphylococcus aureus strain 03-RR-88

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW973_RS09575 Protein ID WP_000031108.1
Coordinates 1964705..1964857 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag NW973_RS09580 Protein ID WP_001251230.1
Coordinates 1964882..1965481 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW973_RS09560 (NW973_09560) 1960499..1961320 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW973_RS09565 (NW973_09565) 1961783..1963168 - 1386 WP_000116229.1 class II fumarate hydratase -
NW973_RS09570 (NW973_09570) 1963364..1963759 - 396 WP_000901023.1 hypothetical protein -
NW973_RS09575 (NW973_09575) 1964705..1964857 - 153 WP_000031108.1 SAS053 family protein Toxin
NW973_RS09580 (NW973_09580) 1964882..1965481 - 600 WP_001251230.1 hypothetical protein Antitoxin
NW973_RS09585 (NW973_09585) 1965640..1966110 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW973_RS09590 (NW973_09590) 1966115..1967242 - 1128 WP_000379988.1 tRNA epoxyqueuosine(34) reductase QueG -
NW973_RS09595 (NW973_09595) 1967393..1968115 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW973_RS09600 (NW973_09600) 1968108..1969565 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254668 WP_000031108.1 NZ_CP102961:c1964857-1964705 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22369.51 Da        Isoelectric Point: 4.9728

>AT254668 WP_001251230.1 NZ_CP102961:c1965481-1964882 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKYAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References