Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2065533..2066047 Replicon chromosome
Accession NZ_CP102960
Organism Staphylococcus aureus strain 07-G-D

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW949_RS10015 Protein ID WP_000581792.1
Coordinates 2065533..2065742 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW949_RS10020 Protein ID WP_000138932.1
Coordinates 2065754..2066047 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW949_RS09995 (NW949_09995) 2061041..2062399 - 1359 WP_006190765.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW949_RS10000 (NW949_10000) 2062414..2063484 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW949_RS10005 (NW949_10005) 2063802..2065004 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW949_RS10010 (NW949_10010) 2065268..2065405 - 138 WP_000828354.1 Lmo0850 family protein -
NW949_RS10015 (NW949_10015) 2065533..2065742 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW949_RS10020 (NW949_10020) 2065754..2066047 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW949_RS10025 (NW949_10025) 2066213..2067697 + 1485 WP_258415321.1 cardiolipin synthase -
NW949_RS10030 (NW949_10030) 2067725..2068372 + 648 WP_001187630.1 HD domain-containing protein -
NW949_RS10035 (NW949_10035) 2068943..2069815 - 873 WP_000725802.1 membrane protein insertase YidC -
NW949_RS10040 (NW949_10040) 2069901..2070542 - 642 WP_258412245.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254660 WP_000581792.1 NZ_CP102960:c2065742-2065533 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254660 WP_000138932.1 NZ_CP102960:c2066047-2065754 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References