Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2045792..2046321 Replicon chromosome
Accession NZ_CP102960
Organism Staphylococcus aureus strain 07-G-D

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW949_RS09925 Protein ID WP_000621175.1
Coordinates 2045792..2046154 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW949_RS09930 Protein ID WP_000948331.1
Coordinates 2046151..2046321 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW949_RS09905 (NW949_09905) 2042770..2043540 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
NW949_RS09910 (NW949_09910) 2043515..2043994 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW949_RS09915 (NW949_09915) 2043996..2044322 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW949_RS09920 (NW949_09920) 2044441..2045442 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW949_RS09925 (NW949_09925) 2045792..2046154 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW949_RS09930 (NW949_09930) 2046151..2046321 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW949_RS09935 (NW949_09935) 2046406..2047554 - 1149 WP_258415319.1 alanine racemase -
NW949_RS09940 (NW949_09940) 2047620..2047979 - 360 WP_000581200.1 holo-ACP synthase -
NW949_RS09945 (NW949_09945) 2047983..2048474 - 492 WP_001205910.1 PH domain-containing protein -
NW949_RS09950 (NW949_09950) 2048461..2050044 - 1584 WP_258415320.1 PH domain-containing protein -
NW949_RS09955 (NW949_09955) 2050037..2050516 - 480 WP_001287079.1 hypothetical protein -
NW949_RS09960 (NW949_09960) 2050725..2051285 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254659 WP_000621175.1 NZ_CP102960:c2046154-2045792 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254659 WP_000948331.1 NZ_CP102960:c2046321-2046151 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References