Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1885232..1886008 Replicon chromosome
Accession NZ_CP102960
Organism Staphylococcus aureus strain 07-G-D

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW949_RS08995 Protein ID WP_000031108.1
Coordinates 1885232..1885384 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW949_RS09000 Protein ID WP_001251224.1
Coordinates 1885409..1886008 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW949_RS08975 (NW949_08975) 1881180..1881251 - 72 Protein_1756 hypothetical protein -
NW949_RS08980 (NW949_08980) 1881254..1882573 - 1320 WP_258415554.1 ISL3-like element IS1181 family transposase -
NW949_RS08985 (NW949_08985) 1882712..1884097 - 1386 WP_000116229.1 class II fumarate hydratase -
NW949_RS08990 (NW949_08990) 1884293..1884688 - 396 WP_000901023.1 hypothetical protein -
NW949_RS08995 (NW949_08995) 1885232..1885384 - 153 WP_000031108.1 SAS053 family protein Toxin
NW949_RS09000 (NW949_09000) 1885409..1886008 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW949_RS09005 (NW949_09005) 1886167..1886637 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW949_RS09010 (NW949_09010) 1886642..1887769 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW949_RS09015 (NW949_09015) 1887920..1888642 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW949_RS09020 (NW949_09020) 1888635..1890092 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1832939..1888648 55709
- flank IS/Tn - - 1881254..1882573 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254658 WP_000031108.1 NZ_CP102960:c1885384-1885232 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254658 WP_001251224.1 NZ_CP102960:c1886008-1885409 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References