Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2079124..2079638 Replicon chromosome
Accession NZ_CP102959
Organism Staphylococcus aureus strain 12-G-51

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag NW979_RS10025 Protein ID WP_000581793.1
Coordinates 2079124..2079333 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW979_RS10030 Protein ID WP_000138932.1
Coordinates 2079345..2079638 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW979_RS10005 (NW979_10005) 2074632..2075990 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW979_RS10010 (NW979_10010) 2076005..2077075 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW979_RS10015 (NW979_10015) 2077393..2078595 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW979_RS10020 (NW979_10020) 2078859..2078996 - 138 WP_000828354.1 Lmo0850 family protein -
NW979_RS10025 (NW979_10025) 2079124..2079333 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
NW979_RS10030 (NW979_10030) 2079345..2079638 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW979_RS10035 (NW979_10035) 2079804..2081288 + 1485 WP_000571549.1 cardiolipin synthase -
NW979_RS10040 (NW979_10040) 2081316..2081963 + 648 WP_001187634.1 HD domain-containing protein -
NW979_RS10045 (NW979_10045) 2082690..2083562 - 873 WP_000725802.1 membrane protein insertase YidC -
NW979_RS10050 (NW979_10050) 2083648..2084289 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T254653 WP_000581793.1 NZ_CP102959:c2079333-2079124 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254653 WP_000138932.1 NZ_CP102959:c2079638-2079345 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References