Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1902542..1903318 Replicon chromosome
Accession NZ_CP102959
Organism Staphylococcus aureus strain 12-G-51

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag NW979_RS09020 Protein ID WP_258413447.1
Coordinates 1902542..1902694 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW979_RS09025 Protein ID WP_001251224.1
Coordinates 1902719..1903318 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW979_RS09000 (NW979_09000) 1898509..1899330 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW979_RS09005 (NW979_09005) 1899791..1901176 - 1386 WP_000116229.1 class II fumarate hydratase -
NW979_RS09010 (NW979_09010) 1901372..1901767 - 396 WP_000901023.1 hypothetical protein -
NW979_RS09015 (NW979_09015) 1901886..1902323 + 438 WP_258413446.1 hypothetical protein -
NW979_RS09020 (NW979_09020) 1902542..1902694 - 153 WP_258413447.1 SAS053 family protein Toxin
NW979_RS09025 (NW979_09025) 1902719..1903318 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW979_RS09030 (NW979_09030) 1903477..1903947 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW979_RS09035 (NW979_09035) 1903952..1905079 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW979_RS09040 (NW979_09040) 1905230..1905952 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW979_RS09045 (NW979_09045) 1905945..1907402 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5935.29 Da        Isoelectric Point: 3.9367

>T254651 WP_258413447.1 NZ_CP102959:c1902694-1902542 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEQDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254651 WP_001251224.1 NZ_CP102959:c1903318-1902719 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References