Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2417390..2417913 Replicon chromosome
Accession NZ_CP102958
Organism Staphylococcus aureus strain 15-G-54

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag NW969_RS11760 Protein ID WP_000074049.1
Coordinates 2417390..2417656 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NW969_RS11765 Protein ID WP_061385136.1
Coordinates 2417656..2417913 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW969_RS11740 (NW969_11740) 2412697..2413884 - 1188 WP_000026189.1 MFS transporter -
NW969_RS11745 (NW969_11745) 2414280..2415056 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
NW969_RS11750 (NW969_11750) 2415049..2415711 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW969_RS11755 (NW969_11755) 2415959..2417035 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW969_RS11760 (NW969_11760) 2417390..2417656 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
NW969_RS11765 (NW969_11765) 2417656..2417913 - 258 WP_061385136.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW969_RS11770 (NW969_11770) 2418272..2418727 + 456 WP_000732076.1 DUF1307 domain-containing protein -
NW969_RS11775 (NW969_11775) 2418895..2420472 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NW969_RS11780 (NW969_11780) 2420667..2421416 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T254649 WP_000074049.1 NZ_CP102958:c2417656-2417390 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9773.75 Da        Isoelectric Point: 4.2086

>AT254649 WP_061385136.1 NZ_CP102958:c2417913-2417656 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWNNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure

References