Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2031146..2031660 Replicon chromosome
Accession NZ_CP102958
Organism Staphylococcus aureus strain 15-G-54

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW969_RS09785 Protein ID WP_000581792.1
Coordinates 2031146..2031355 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW969_RS09790 Protein ID WP_000138932.1
Coordinates 2031367..2031660 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW969_RS09765 (NW969_09765) 2026654..2028012 - 1359 WP_258411762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW969_RS09770 (NW969_09770) 2028027..2029097 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW969_RS09775 (NW969_09775) 2029415..2030617 + 1203 WP_054190441.1 FtsW/RodA/SpoVE family cell cycle protein -
NW969_RS09780 (NW969_09780) 2030881..2031018 - 138 WP_000828354.1 Lmo0850 family protein -
NW969_RS09785 (NW969_09785) 2031146..2031355 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW969_RS09790 (NW969_09790) 2031367..2031660 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW969_RS09795 (NW969_09795) 2031826..2033310 + 1485 WP_000571549.1 cardiolipin synthase -
NW969_RS09800 (NW969_09800) 2033338..2033985 + 648 WP_258411763.1 HD domain-containing protein -
NW969_RS09805 (NW969_09805) 2034799..2035671 - 873 WP_000725802.1 membrane protein insertase YidC -
NW969_RS09810 (NW969_09810) 2035757..2036398 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254645 WP_000581792.1 NZ_CP102958:c2031355-2031146 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254645 WP_000138932.1 NZ_CP102958:c2031660-2031367 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References