Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2011405..2011934 Replicon chromosome
Accession NZ_CP102958
Organism Staphylococcus aureus strain 15-G-54

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW969_RS09695 Protein ID WP_000621175.1
Coordinates 2011405..2011767 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW969_RS09700 Protein ID WP_000948331.1
Coordinates 2011764..2011934 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW969_RS09675 (NW969_09675) 2008383..2009153 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW969_RS09680 (NW969_09680) 2009128..2009607 - 480 WP_258413936.1 anti-sigma B factor RsbW -
NW969_RS09685 (NW969_09685) 2009609..2009935 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW969_RS09690 (NW969_09690) 2010054..2011055 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW969_RS09695 (NW969_09695) 2011405..2011767 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW969_RS09700 (NW969_09700) 2011764..2011934 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW969_RS09705 (NW969_09705) 2012019..2013167 - 1149 WP_001281154.1 alanine racemase -
NW969_RS09710 (NW969_09710) 2013233..2013592 - 360 WP_000581197.1 holo-ACP synthase -
NW969_RS09715 (NW969_09715) 2013596..2014087 - 492 WP_001205912.1 PH domain-containing protein -
NW969_RS09720 (NW969_09720) 2014074..2015657 - 1584 WP_258413937.1 PH domain-containing protein -
NW969_RS09725 (NW969_09725) 2015650..2016129 - 480 WP_001287078.1 hypothetical protein -
NW969_RS09730 (NW969_09730) 2016338..2016898 - 561 WP_061838823.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254644 WP_000621175.1 NZ_CP102958:c2011767-2011405 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254644 WP_000948331.1 NZ_CP102958:c2011934-2011764 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References