Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1850811..1851587 Replicon chromosome
Accession NZ_CP102958
Organism Staphylococcus aureus strain 15-G-54

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW969_RS08760 Protein ID WP_000031108.1
Coordinates 1850811..1850963 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW969_RS08765 Protein ID WP_001251224.1
Coordinates 1850988..1851587 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW969_RS08745 (NW969_08745) 1846840..1847661 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW969_RS08750 (NW969_08750) 1848124..1849509 - 1386 WP_258413920.1 class II fumarate hydratase -
NW969_RS08755 (NW969_08755) 1849705..1850100 - 396 WP_000901023.1 hypothetical protein -
NW969_RS08760 (NW969_08760) 1850811..1850963 - 153 WP_000031108.1 SAS053 family protein Toxin
NW969_RS08765 (NW969_08765) 1850988..1851587 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW969_RS08770 (NW969_08770) 1851746..1852216 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW969_RS08775 (NW969_08775) 1852221..1853348 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
NW969_RS08780 (NW969_08780) 1853499..1854221 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW969_RS08785 (NW969_08785) 1854214..1855671 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254643 WP_000031108.1 NZ_CP102958:c1850963-1850811 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254643 WP_001251224.1 NZ_CP102958:c1851587-1850988 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References