254640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2433859..2434382 Replicon chromosome
Accession NZ_CP102957
Organism Staphylococcus aureus strain 18-H-62

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NW959_RS11940 Protein ID WP_258411852.1
Coordinates 2433859..2434125 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag NW959_RS11945 Protein ID WP_000587617.1
Coordinates 2434125..2434382 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW959_RS11920 (NW959_11920) 2429165..2430352 - 1188 WP_000026189.1 MFS transporter -
NW959_RS11925 (NW959_11925) 2430748..2431524 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
NW959_RS11930 (NW959_11930) 2431517..2432179 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
NW959_RS11935 (NW959_11935) 2432427..2433503 - 1077 WP_258411851.1 M42 family metallopeptidase -
NW959_RS11940 (NW959_11940) 2433859..2434125 - 267 WP_258411852.1 Txe/YoeB family addiction module toxin Toxin
NW959_RS11945 (NW959_11945) 2434125..2434382 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW959_RS11950 (NW959_11950) 2434741..2435196 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NW959_RS11955 (NW959_11955) 2435364..2436941 - 1578 WP_258411853.1 FMN-binding glutamate synthase family protein -
NW959_RS11960 (NW959_11960) 2437138..2437887 + 750 WP_006191031.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(28-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.37 Da        Isoelectric Point: 10.2763

>T254640 WP_258411852.1 NZ_CP102957:c2434125-2433859 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT254640 WP_000587617.1 NZ_CP102957:c2434382-2434125 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References