Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2036977..2037491 Replicon chromosome
Accession NZ_CP102957
Organism Staphylococcus aureus strain 18-H-62

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW959_RS09890 Protein ID WP_000581792.1
Coordinates 2036977..2037186 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW959_RS09895 Protein ID WP_000138932.1
Coordinates 2037198..2037491 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW959_RS09870 (NW959_09870) 2032485..2033843 - 1359 WP_000611481.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW959_RS09875 (NW959_09875) 2033858..2034928 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW959_RS09880 (NW959_09880) 2035246..2036448 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW959_RS09885 (NW959_09885) 2036712..2036849 - 138 WP_000828354.1 Lmo0850 family protein -
NW959_RS09890 (NW959_09890) 2036977..2037186 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW959_RS09895 (NW959_09895) 2037198..2037491 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW959_RS09900 (NW959_09900) 2037657..2039141 + 1485 WP_000571549.1 cardiolipin synthase -
NW959_RS09905 (NW959_09905) 2039169..2039816 + 648 WP_001187630.1 HD domain-containing protein -
NW959_RS09910 (NW959_09910) 2040387..2041259 - 873 WP_000725802.1 membrane protein insertase YidC -
NW959_RS09915 (NW959_09915) 2041345..2041986 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254636 WP_000581792.1 NZ_CP102957:c2037186-2036977 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254636 WP_000138932.1 NZ_CP102957:c2037491-2037198 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References