254635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2017219..2017748 Replicon chromosome
Accession NZ_CP102957
Organism Staphylococcus aureus strain 18-H-62

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW959_RS09800 Protein ID WP_000621175.1
Coordinates 2017219..2017581 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW959_RS09805 Protein ID WP_000948331.1
Coordinates 2017578..2017748 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW959_RS09780 (NW959_09780) 2014197..2014967 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW959_RS09785 (NW959_09785) 2014942..2015421 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW959_RS09790 (NW959_09790) 2015423..2015749 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW959_RS09795 (NW959_09795) 2015868..2016869 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW959_RS09800 (NW959_09800) 2017219..2017581 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW959_RS09805 (NW959_09805) 2017578..2017748 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW959_RS09810 (NW959_09810) 2017833..2018981 - 1149 WP_072496962.1 alanine racemase -
NW959_RS09815 (NW959_09815) 2019047..2019406 - 360 WP_061838820.1 holo-ACP synthase -
NW959_RS09820 (NW959_09820) 2019410..2019901 - 492 WP_072496961.1 PH domain-containing protein -
NW959_RS09825 (NW959_09825) 2019888..2021471 - 1584 WP_258414916.1 PH domain-containing protein -
NW959_RS09830 (NW959_09830) 2021464..2021943 - 480 WP_001287079.1 hypothetical protein -
NW959_RS09835 (NW959_09835) 2022152..2022712 - 561 WP_072496959.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254635 WP_000621175.1 NZ_CP102957:c2017581-2017219 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254635 WP_000948331.1 NZ_CP102957:c2017748-2017578 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References