Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1862479..1863255 Replicon chromosome
Accession NZ_CP102957
Organism Staphylococcus aureus strain 18-H-62

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW959_RS08905 Protein ID WP_000031108.1
Coordinates 1862479..1862631 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW959_RS08910 Protein ID WP_001251224.1
Coordinates 1862656..1863255 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW959_RS08890 (NW959_08890) 1858618..1859439 + 822 WP_258472915.1 RluA family pseudouridine synthase -
NW959_RS08895 (NW959_08895) 1859902..1861287 - 1386 WP_000116231.1 class II fumarate hydratase -
NW959_RS08900 (NW959_08900) 1861483..1861878 - 396 WP_000901021.1 hypothetical protein -
NW959_RS08905 (NW959_08905) 1862479..1862631 - 153 WP_000031108.1 SAS053 family protein Toxin
NW959_RS08910 (NW959_08910) 1862656..1863255 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW959_RS08915 (NW959_08915) 1863414..1863884 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW959_RS08920 (NW959_08920) 1863889..1865016 - 1128 WP_258472918.1 tRNA epoxyqueuosine(34) reductase QueG -
NW959_RS08925 (NW959_08925) 1865167..1865889 - 723 WP_258472919.1 amino acid ABC transporter ATP-binding protein -
NW959_RS08930 (NW959_08930) 1865882..1867339 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254634 WP_000031108.1 NZ_CP102957:c1862631-1862479 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254634 WP_001251224.1 NZ_CP102957:c1863255-1862656 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References