Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2204215..2204759 | Replicon | chromosome |
| Accession | NC_015758 | ||
| Organism | Mycobacterium africanum GM041182 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | MAF_RS10240 | Protein ID | WP_003409896.1 |
| Coordinates | 2204215..2204511 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | MAF_RS10245 | Protein ID | WP_003409899.1 |
| Coordinates | 2204508..2204759 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAF_RS10185 | 2199248..2199598 | - | 351 | WP_003910480.1 | hypothetical protein | - |
| MAF_RS10190 | 2199609..2200511 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| MAF_RS10195 | 2200532..2200723 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| MAF_RS10200 | 2200724..2201020 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| MAF_RS10205 | 2201260..2201475 | + | 216 | WP_003409878.1 | antitoxin | - |
| MAF_RS10210 | 2201472..2201783 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| MAF_RS22135 | 2201757..2202278 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| MAF_RS10220 | 2202253..2202630 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| MAF_RS10225 | 2202672..2203121 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| MAF_RS10230 | 2203118..2203663 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| MAF_RS10235 | 2203552..2204166 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| MAF_RS10240 | 2204215..2204511 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MAF_RS10245 | 2204508..2204759 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| MAF_RS10250 | 2204746..2205240 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| MAF_RS10255 | 2205400..2205807 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| MAF_RS10260 | 2205811..2206083 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MAF_RS10265 | 2206116..2207336 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| MAF_RS10275 | 2208235..2208540 | + | 306 | Protein_2016 | ABC transporter permease | - |
| MAF_RS10280 | 2208724..2209572 | + | 849 | WP_003910485.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T25463 WP_003409896.1 NC_015758:c2204511-2204215 [Mycobacterium tuberculosis variant africanum GM041182]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T25463 NC_015758:c2204511-2204215 [Mycobacterium tuberculosis variant africanum GM041182]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT25463 WP_003409899.1 NC_015758:c2204759-2204508 [Mycobacterium tuberculosis variant africanum GM041182]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT25463 NC_015758:c2204759-2204508 [Mycobacterium tuberculosis variant africanum GM041182]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |