254627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2039194..2039723 Replicon chromosome
Accession NZ_CP102956
Organism Staphylococcus aureus strain 26-G-G

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW981_RS09920 Protein ID WP_000621175.1
Coordinates 2039194..2039556 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW981_RS09925 Protein ID WP_000948331.1
Coordinates 2039553..2039723 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW981_RS09900 (NW981_09900) 2036172..2036942 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
NW981_RS09905 (NW981_09905) 2036917..2037396 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW981_RS09910 (NW981_09910) 2037398..2037724 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW981_RS09915 (NW981_09915) 2037843..2038844 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW981_RS09920 (NW981_09920) 2039194..2039556 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW981_RS09925 (NW981_09925) 2039553..2039723 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW981_RS09930 (NW981_09930) 2039808..2040956 - 1149 WP_001281154.1 alanine racemase -
NW981_RS09935 (NW981_09935) 2041022..2041381 - 360 WP_000581200.1 holo-ACP synthase -
NW981_RS09940 (NW981_09940) 2041385..2041876 - 492 WP_001205912.1 PH domain-containing protein -
NW981_RS09945 (NW981_09945) 2041863..2043446 - 1584 WP_258410134.1 PH domain-containing protein -
NW981_RS09950 (NW981_09950) 2043439..2043918 - 480 WP_216712621.1 hypothetical protein -
NW981_RS09955 (NW981_09955) 2044127..2044687 - 561 WP_258410135.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254627 WP_000621175.1 NZ_CP102956:c2039556-2039194 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254627 WP_000948331.1 NZ_CP102956:c2039723-2039553 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References