Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1882936..1883712 Replicon chromosome
Accession NZ_CP102956
Organism Staphylococcus aureus strain 26-G-G

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag NW981_RS09025 Protein ID WP_258410104.1
Coordinates 1882936..1883088 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW981_RS09030 Protein ID WP_001251224.1
Coordinates 1883113..1883712 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW981_RS09010 (NW981_09010) 1878896..1879717 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW981_RS09015 (NW981_09015) 1880178..1881563 - 1386 WP_258410103.1 class II fumarate hydratase -
NW981_RS09020 (NW981_09020) 1881759..1882154 - 396 WP_000901023.1 hypothetical protein -
NW981_RS09025 (NW981_09025) 1882936..1883088 - 153 WP_258410104.1 SAS053 family protein Toxin
NW981_RS09030 (NW981_09030) 1883113..1883712 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW981_RS09035 (NW981_09035) 1883871..1884341 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW981_RS09040 (NW981_09040) 1884346..1885473 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW981_RS09045 (NW981_09045) 1885624..1886346 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW981_RS09050 (NW981_09050) 1886339..1887796 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5918.25 Da        Isoelectric Point: 3.8962

>T254626 WP_258410104.1 NZ_CP102956:c1883088-1882936 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSIVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254626 WP_001251224.1 NZ_CP102956:c1883712-1883113 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References