254620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 2083498..2084012 Replicon chromosome
Accession NZ_CP102955
Organism Staphylococcus aureus strain 28-G-I

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW961_RS10185 Protein ID WP_000581792.1
Coordinates 2083498..2083707 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW961_RS10190 Protein ID WP_000138932.1
Coordinates 2083719..2084012 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW961_RS10165 (NW961_10165) 2079006..2080364 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW961_RS10170 (NW961_10170) 2080379..2081449 - 1071 WP_000159632.1 D-alanine--D-alanine ligase -
NW961_RS10175 (NW961_10175) 2081767..2082969 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW961_RS10180 (NW961_10180) 2083233..2083370 - 138 WP_000828354.1 Lmo0850 family protein -
NW961_RS10185 (NW961_10185) 2083498..2083707 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW961_RS10190 (NW961_10190) 2083719..2084012 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW961_RS10195 (NW961_10195) 2084178..2085662 + 1485 WP_000571549.1 cardiolipin synthase -
NW961_RS10200 (NW961_10200) 2085690..2086337 + 648 WP_001187634.1 HD domain-containing protein -
NW961_RS10205 (NW961_10205) 2087053..2087925 - 873 WP_000725802.1 membrane protein insertase YidC -
NW961_RS10210 (NW961_10210) 2088011..2088652 - 642 WP_258412245.1 thiamine phosphate synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254620 WP_000581792.1 NZ_CP102955:c2083707-2083498 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp


Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254620 WP_000138932.1 NZ_CP102955:c2084012-2083719 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6FF1


Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References