Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2063740..2064269 Replicon chromosome
Accession NZ_CP102955
Organism Staphylococcus aureus strain 28-G-I

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW961_RS10095 Protein ID WP_000621175.1
Coordinates 2063740..2064102 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW961_RS10100 Protein ID WP_000948331.1
Coordinates 2064099..2064269 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW961_RS10075 (NW961_10075) 2060718..2061488 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
NW961_RS10080 (NW961_10080) 2061463..2061942 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW961_RS10085 (NW961_10085) 2061944..2062270 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW961_RS10090 (NW961_10090) 2062389..2063390 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW961_RS10095 (NW961_10095) 2063740..2064102 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW961_RS10100 (NW961_10100) 2064099..2064269 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW961_RS10105 (NW961_10105) 2064354..2065502 - 1149 WP_258415625.1 alanine racemase -
NW961_RS10110 (NW961_10110) 2065568..2065927 - 360 WP_061838820.1 holo-ACP synthase -
NW961_RS10115 (NW961_10115) 2065931..2066422 - 492 WP_072353916.1 PH domain-containing protein -
NW961_RS10120 (NW961_10120) 2066409..2067992 - 1584 WP_258415626.1 PH domain-containing protein -
NW961_RS10125 (NW961_10125) 2067985..2068464 - 480 WP_258410777.1 hypothetical protein -
NW961_RS10130 (NW961_10130) 2068673..2069233 - 561 WP_001092416.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254619 WP_000621175.1 NZ_CP102955:c2064102-2063740 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254619 WP_000948331.1 NZ_CP102955:c2064269-2064099 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References