Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1910046..1910822 Replicon chromosome
Accession NZ_CP102955
Organism Staphylococcus aureus strain 28-G-I

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW961_RS09210 Protein ID WP_000031108.1
Coordinates 1910046..1910198 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW961_RS09215 Protein ID WP_001251224.1
Coordinates 1910223..1910822 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW961_RS09195 (NW961_09195) 1906238..1907059 + 822 WP_045174097.1 RluA family pseudouridine synthase -
NW961_RS09200 (NW961_09200) 1907522..1908907 - 1386 WP_000116231.1 class II fumarate hydratase -
NW961_RS09205 (NW961_09205) 1909103..1909498 - 396 WP_000901023.1 hypothetical protein -
NW961_RS09210 (NW961_09210) 1910046..1910198 - 153 WP_000031108.1 SAS053 family protein Toxin
NW961_RS09215 (NW961_09215) 1910223..1910822 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW961_RS09220 (NW961_09220) 1910981..1911451 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW961_RS09225 (NW961_09225) 1911456..1912583 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW961_RS09230 (NW961_09230) 1912735..1913457 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW961_RS09235 (NW961_09235) 1913450..1914907 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254618 WP_000031108.1 NZ_CP102955:c1910198-1910046 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254618 WP_001251224.1 NZ_CP102955:c1910822-1910223 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References