Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2083554..2084068 Replicon chromosome
Accession NZ_CP102954
Organism Staphylococcus aureus strain 30-P-10

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW951_RS10120 Protein ID WP_000581792.1
Coordinates 2083554..2083763 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW951_RS10125 Protein ID WP_000138932.1
Coordinates 2083775..2084068 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW951_RS10100 (NW951_10100) 2079062..2080420 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW951_RS10105 (NW951_10105) 2080435..2081505 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW951_RS10110 (NW951_10110) 2081823..2083025 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW951_RS10115 (NW951_10115) 2083289..2083426 - 138 WP_000828354.1 Lmo0850 family protein -
NW951_RS10120 (NW951_10120) 2083554..2083763 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW951_RS10125 (NW951_10125) 2083775..2084068 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW951_RS10130 (NW951_10130) 2084234..2085718 + 1485 WP_000571549.1 cardiolipin synthase -
NW951_RS10135 (NW951_10135) 2085746..2086393 + 648 WP_001187629.1 HD domain-containing protein -
NW951_RS10140 (NW951_10140) 2087007..2087879 - 873 WP_000725802.1 membrane protein insertase YidC -
NW951_RS10145 (NW951_10145) 2087965..2088606 - 642 WP_258412245.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254609 WP_000581792.1 NZ_CP102954:c2083763-2083554 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254609 WP_000138932.1 NZ_CP102954:c2084068-2083775 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References