Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2063797..2064326 Replicon chromosome
Accession NZ_CP102954
Organism Staphylococcus aureus strain 30-P-10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW951_RS10030 Protein ID WP_000621175.1
Coordinates 2063797..2064159 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW951_RS10035 Protein ID WP_000948331.1
Coordinates 2064156..2064326 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW951_RS10010 (NW951_10010) 2060775..2061545 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW951_RS10015 (NW951_10015) 2061520..2061999 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW951_RS10020 (NW951_10020) 2062001..2062327 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW951_RS10025 (NW951_10025) 2062446..2063447 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW951_RS10030 (NW951_10030) 2063797..2064159 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW951_RS10035 (NW951_10035) 2064156..2064326 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW951_RS10040 (NW951_10040) 2064411..2065559 - 1149 WP_001281145.1 alanine racemase -
NW951_RS10045 (NW951_10045) 2065625..2065984 - 360 WP_000581197.1 holo-ACP synthase -
NW951_RS10050 (NW951_10050) 2065988..2066479 - 492 WP_001205912.1 PH domain-containing protein -
NW951_RS10055 (NW951_10055) 2066466..2068049 - 1584 WP_001294620.1 PH domain-containing protein -
NW951_RS10060 (NW951_10060) 2068042..2068521 - 480 WP_001287079.1 hypothetical protein -
NW951_RS10065 (NW951_10065) 2068730..2069290 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254608 WP_000621175.1 NZ_CP102954:c2064159-2063797 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254608 WP_000948331.1 NZ_CP102954:c2064326-2064156 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References