Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1902991..1903767 Replicon chromosome
Accession NZ_CP102954
Organism Staphylococcus aureus strain 30-P-10

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW951_RS09100 Protein ID WP_000031108.1
Coordinates 1902991..1903143 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW951_RS09105 Protein ID WP_001251224.1
Coordinates 1903168..1903767 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW951_RS09085 (NW951_09085) 1898968..1899789 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW951_RS09090 (NW951_09090) 1900241..1901626 - 1386 WP_000116229.1 class II fumarate hydratase -
NW951_RS09095 (NW951_09095) 1901822..1902217 - 396 WP_000901023.1 hypothetical protein -
NW951_RS09100 (NW951_09100) 1902991..1903143 - 153 WP_000031108.1 SAS053 family protein Toxin
NW951_RS09105 (NW951_09105) 1903168..1903767 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW951_RS09110 (NW951_09110) 1903927..1904397 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW951_RS09115 (NW951_09115) 1904402..1905529 - 1128 WP_258413072.1 tRNA epoxyqueuosine(34) reductase QueG -
NW951_RS09120 (NW951_09120) 1905680..1906402 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW951_RS09125 (NW951_09125) 1906395..1907852 - 1458 WP_258413073.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254607 WP_000031108.1 NZ_CP102954:c1903143-1902991 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254607 WP_001251224.1 NZ_CP102954:c1903767-1903168 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References