Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2478594..2479117 Replicon chromosome
Accession NZ_CP102953
Organism Staphylococcus aureus strain 32-T-13

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NW977_RS12260 Protein ID WP_258412665.1
Coordinates 2478594..2478860 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag NW977_RS12265 Protein ID WP_000587617.1
Coordinates 2478860..2479117 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW977_RS12240 (NW977_12240) 2473899..2475086 - 1188 WP_000026189.1 MFS transporter -
NW977_RS12245 (NW977_12245) 2475482..2476258 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW977_RS12250 (NW977_12250) 2476251..2476913 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW977_RS12255 (NW977_12255) 2477161..2478237 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW977_RS12260 (NW977_12260) 2478594..2478860 - 267 WP_258412665.1 Txe/YoeB family addiction module toxin Toxin
NW977_RS12265 (NW977_12265) 2478860..2479117 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW977_RS12270 (NW977_12270) 2479477..2479932 + 456 WP_000732076.1 DUF1307 domain-containing protein -
NW977_RS12275 (NW977_12275) 2480100..2481677 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NW977_RS12280 (NW977_12280) 2481872..2482621 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10704.30 Da        Isoelectric Point: 10.1597

>T254605 WP_258412665.1 NZ_CP102953:c2478860-2478594 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHTYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT254605 WP_000587617.1 NZ_CP102953:c2479117-2478860 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References