25460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1960161..1960621 Replicon chromosome
Accession NC_015758
Organism Mycobacterium africanum GM041182

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag MAF_RS09135 Protein ID WP_003408531.1
Coordinates 1960373..1960621 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag MAF_RS09130 Protein ID WP_003408528.1
Coordinates 1960161..1960373 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAF_RS09115 1956639..1957826 - 1188 WP_003898992.1 nitrate transporter NarK -
MAF_RS09120 1958113..1958397 + 285 WP_003408522.1 DUF1876 domain-containing protein -
MAF_RS09125 1958411..1960093 - 1683 WP_013988872.1 SulP family inorganic anion transporter -
MAF_RS09130 1960161..1960373 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MAF_RS09135 1960373..1960621 + 249 WP_003408531.1 hypothetical protein Toxin
MAF_RS09140 1960629..1961367 + 739 Protein_1789 hypothetical protein -
MAF_RS09145 1961461..1963161 + 1701 WP_003910425.1 serine/threonine protein kinase PknE -
MAF_RS09150 1963446..1963847 - 402 WP_003408538.1 hypothetical protein -
MAF_RS09155 1963837..1964448 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T25460 WP_003408531.1 NC_015758:1960373-1960621 [Mycobacterium tuberculosis variant africanum GM041182]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T25460 NC_015758:1960373-1960621 [Mycobacterium tuberculosis variant africanum GM041182]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT25460 WP_003408528.1 NC_015758:1960161-1960373 [Mycobacterium tuberculosis variant africanum GM041182]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT25460 NC_015758:1960161-1960373 [Mycobacterium tuberculosis variant africanum GM041182]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References