254599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2052534..2053048 Replicon chromosome
Accession NZ_CP102953
Organism Staphylococcus aureus strain 32-T-13

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW977_RS09970 Protein ID WP_000581792.1
Coordinates 2052534..2052743 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW977_RS09975 Protein ID WP_000138932.1
Coordinates 2052755..2053048 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW977_RS09950 (NW977_09950) 2048042..2049400 - 1359 WP_000611481.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW977_RS09955 (NW977_09955) 2049415..2050485 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW977_RS09960 (NW977_09960) 2050803..2052005 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW977_RS09965 (NW977_09965) 2052269..2052406 - 138 WP_000828354.1 Lmo0850 family protein -
NW977_RS09970 (NW977_09970) 2052534..2052743 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW977_RS09975 (NW977_09975) 2052755..2053048 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW977_RS09980 (NW977_09980) 2053214..2054698 + 1485 WP_000571549.1 cardiolipin synthase -
NW977_RS09985 (NW977_09985) 2054726..2055373 + 648 WP_258411763.1 HD domain-containing protein -
NW977_RS09990 (NW977_09990) 2056187..2057059 - 873 WP_000725802.1 membrane protein insertase YidC -
NW977_RS09995 (NW977_09995) 2057145..2057786 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254599 WP_000581792.1 NZ_CP102953:c2052743-2052534 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254599 WP_000138932.1 NZ_CP102953:c2053048-2052755 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References